锂作用机制研究的临床意义

Clinical implications of research on the mechanism of action of lithium.

作者信息

Belmaker R H, Lerer B, Klein E, Newman M, Dick E

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(2-3):287-96. doi: 10.1016/0278-5846(83)90118-5.

Abstract

Lithium is a unique drug in its clinical profile in psychiatry. Lithium has numerous biochemical effects, but none has yet been proven to be its mode of therapeutic action. Inhibition of noradrenaline-sensitive adenylate cyclase is reviewed as the only biochemical effect of lithium shown to occur in both animals and man at therapeutic lithium concentrations. A tetracycline antibiotic, demeclocycline, also blocks noradrenaline-sensitive adenylate cyclase. A clinical trial of demeclocycline in mania would provide a test of the adenylate cyclase theory of lithium action.

摘要

锂在精神病学临床应用方面是一种独特的药物。锂具有众多生化效应，但尚未有任何一种效应被证实为其治疗作用方式。抑制去甲肾上腺素敏感的腺苷酸环化酶被视为锂在治疗浓度下在动物和人类中均出现的唯一生化效应。一种四环素抗生素，地美环素，也能阻断去甲肾上腺素敏感的腺苷酸环化酶。地美环素治疗躁狂症的临床试验将对锂作用的腺苷酸环化酶理论进行检验。