Leng B, Imbert Y, Coomans D
Sem Hop. 1983 Jun 30;59(26):1977-80.
Twenty-nine patients, aged 19 to 87, were treated for an infection of the lower respiratory tract (pneumonia, bronchopneumonia, bronchitis, pulmonary abscess, pleuritis) due to a pathogen with in vitro sensitivity to the antibiotic (pneumococcus, hemophilus, anaerobic organisms . . .). Patients were given Moxalactam as the only antibacterial treatment. In most instances, excellent results (24 successes, i.e. 84% of cases) were recorded with two daily intramuscular injections of 1 g each. Biologic tolerance was satisfactory. Possible clinical side-effects are rashes and local pain during the injection. We conclude that Moxalactam is very effective in severe lower respiratory tract infections, with a daily dosage of 30 mg/kg.
29名年龄在19岁至87岁之间的患者因对该抗生素具有体外敏感性的病原体(肺炎球菌、嗜血杆菌、厌氧菌……)导致的下呼吸道感染(肺炎、支气管肺炎、支气管炎、肺脓肿、胸膜炎)接受治疗。患者仅接受了莫拉卡坦作为抗菌治疗。在大多数情况下,每日两次肌肉注射,每次1克,取得了优异的效果(24例成功,即84%的病例)。生物学耐受性良好。可能的临床副作用为皮疹和注射时的局部疼痛。我们得出结论,莫拉卡坦在严重下呼吸道感染中非常有效,每日剂量为30毫克/千克。