Tan J S, Salstrom S J, File T M
Am J Med. 1983 Aug 29;75(2A):65-7. doi: 10.1016/0002-9343(83)90096-7.
Amdinocillin levels in human plasma and interstitial fluid were studied in 12 human volunteers. The results showed that relatively high levels of amdinocillin were detected in the interstitial fluid. The fluid to plasma ratio of the area under the curve was 0.25. This is consistent with high diffusibility as seen in drugs with a low percentage of protein binding.
在12名人类志愿者中研究了氨比西林在人血浆和组织液中的水平。结果显示，在组织液中检测到相对较高水平的氨比西林。曲线下面积的组织液与血浆比值为0.25。这与蛋白质结合率低的药物所具有的高扩散性相一致。
