促肾上腺皮质激素刺激后肾上腺皮质细胞膜胆固醇的分布
Distribution of membrane cholesterol of adrenal cortical cells after corticotropin stimulation.
作者信息
Conneely O M, Greene J M, Headon D R, Hsiao J, Ungar F
出版信息
Biochem J. 1983 Aug 15;214(2):561-7. doi: 10.1042/bj2140561.
Abstract
Membrane cholesterol in adrenal cortical cells is enriched in the plasma membrane. Stimulation of isolated adrenal cortical cells with corticotropin leads to the production of corticosterone. At high levels of corticotropin, cholesterol for corticosterone synthesis arises by hydrolysis of cellular cholesteryl ester, whereas at lower levels of corticotropin cholesteryl ester levels are unchanged from control values and there is a decrease in plasma-membrane cholesterol levels.
摘要
肾上腺皮质细胞中的膜胆固醇在质膜中富集。用促肾上腺皮质激素刺激分离的肾上腺皮质细胞会导致皮质酮的产生。在促肾上腺皮质激素水平较高时，用于皮质酮合成的胆固醇通过细胞胆固醇酯的水解产生，而在促肾上腺皮质激素水平较低时，胆固醇酯水平与对照值相比没有变化，质膜胆固醇水平则有所下降。
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