Serra M, Concas A, Salis M, Biggio G
Brain Res. 1983 Aug 29;273(2):347-51. doi: 10.1016/0006-8993(83)90860-0.
The intraperitoneal administration of DMCM (0.5-3 mg/kg) produced a dose-related increase in the content of cyclic GMP in the rat cerebellar cortex. The effect of DMCM on cyclic GMP was abolished by pretreatment with benzodiazepine receptor ligands, diazepam and Ro15-1788 and by the GABA agonist muscimol. The results suggest that DMCM increases cerebellar cyclic GMP content through a direct action on benzodiazepine receptors located in the cerebellar cortex. The interaction between DMCM and the GABAergic system associated with benzodiazepine receptors is discussed. Cerebellar cyclic GMP content can be used as a biochemical index to differentiate agonists and antagonists for benzodiazepine receptors.
腹腔注射DMCM（0.5 - 3毫克/千克）可使大鼠小脑皮质中环状鸟苷酸（cGMP）的含量呈剂量依赖性增加。苯二氮䓬受体配体地西泮和Ro15 - 1788以及GABA激动剂蝇蕈醇预处理可消除DMCM对cGMP的影响。结果表明，DMCM通过直接作用于位于小脑皮质的苯二氮䓬受体来增加小脑cGMP含量。文中讨论了DMCM与和苯二氮䓬受体相关的GABA能系统之间的相互作用。小脑cGMP含量可用作区分苯二氮䓬受体激动剂和拮抗剂的生化指标。
