Depresseux J C
Eur Neurol. 1978;17(2):100-7. doi: 10.1159/000114931.
The cerebral hemodynamic action of Vincamine is measured in 17 patients with primary or secondary cerebral circulation disorders, by use of the multiregional 133Xe clearance technique. The statistical analysis of the results justifies the grouping of all the cases and the distinction between reference, ischemic and hyperemic zones by determining for each subject a range of + or - 15% of his own mean regional cerebral blood flow. The drug, in a single injection in the internal carotid artery, shows a significant beneficial hemodynamic effect on the ischemic regions of the brain. No steal phenomenon is recorded in the middle cerebral artery territory. The action of the drug leads to a decrease and an equalization of the hemodynamic resistances of the cerebral vascular bed.
采用多区域¹³³Xe清除技术，对17例原发性或继发性脑循环障碍患者测定长春胺的脑血流动力学作用。结果的统计分析通过为每个受试者确定其自身平均局部脑血流量±15%的范围，证明了所有病例的分组以及正常、缺血和充血区域之间的区别。该药经颈内动脉单次注射后，对脑缺血区域显示出显著的有益血流动力学效应。大脑中动脉区域未记录到盗血现象。该药的作用导致脑血管床血流动力学阻力降低并趋于平衡。
