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人体受试者呼出气体中Δ⁹-四氢大麻酚的检测。

The detection of delta 9-tetrahydrocannabinol in the breath of human subjects.

作者信息

Manolis A, McBurney L J, Bobbie B A

出版信息

Clin Biochem. 1983 Aug;16(4):229-33. doi: 10.1016/s0009-9120(83)90070-x.

DOI:10.1016/s0009-9120(83)90070-x
PMID:6311456
Abstract

Delta 9-Tetrahydrocannabinol (THC) was detected in breath of human subjects by gas liquid chromatography/mass spectrometry (GC/MS) up to twelve minutes after smoking marijuana. A number of adsorbents were tested for THC entrapment and subsequent detection (Tenax-GC, ethanol, 0.75 N ethanolic KOH, Amberlite resin XAD-2, and Sephadex G-10). All of these gave poor recoveries. The decay rate of breath THC was much faster than that of plasma THC and there was very poor correlation between breath THC and plasma THC. We conclude that the detection of breath THC is probably due to that emanating from the surface of the mouth and respiratory system.

摘要

通过气液色谱/质谱联用仪(GC/MS)在人体受试者吸食大麻后长达12分钟的呼出气体中检测到了Δ9-四氢大麻酚(THC)。对多种用于截留并随后检测THC的吸附剂进行了测试(Tenax-GC、乙醇、0.75N乙醇氢氧化钾、Amberlite树脂XAD-2和葡聚糖G-10)。所有这些吸附剂的回收率都很低。呼出气体中THC的衰减速率比血浆中THC的衰减速率快得多,且呼出气体THC与血浆THC之间的相关性非常差。我们得出结论,呼出气体中THC的检测可能是由于口腔和呼吸系统表面散发出来的。

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