Wible-Kant J, Beer A E
Clin Perinatol. 1983 Jun;10(2):343-55.
In summary, the routine administration of Rh immune globulin to Rh-negative women at risk has decreased the incidence of isoimmunization from 13 per cent to less than 2 per cent. Studies have shown that with the antepartum administration of 300 micrograms of Rh immune globulin to all Rh-negative women the incidence can be decreased still further to 0.07 per cent. Careful attention must be paid to all possible antepartum sensitizing situations, such as vaginal bleeding, premature labor, amniocenteses, and extrauterine manipulations. Cost-benefit analyses do show that benefits justify the extra expense of +35 to +40 per injection. The benefits and costs of routine Du typing versus its elimination for more sensitive testing remains somewhat controversial at this point.
总之，对有风险的Rh阴性女性常规给予Rh免疫球蛋白已将同种免疫的发生率从13%降至不到2%。研究表明，对所有Rh阴性女性在产前给予300微克Rh免疫球蛋白，发生率可进一步降至0.07%。必须密切关注所有可能的产前致敏情况，如阴道出血、早产、羊膜穿刺术和宫外操作。成本效益分析确实表明，效益证明每次注射额外增加35至40的费用是合理的。目前，常规进行Du血型检测与取消该检测以进行更敏感检测的效益和成本仍存在一定争议。
