Skerritt J H, Johnston G A, Chow S C
Epilepsia. 1983 Oct;24(5):643-50. doi: 10.1111/j.1528-1157.1983.tb03430.x.
The interactions of carbamazepine with adenosine receptors were studied in two pharmacological systems. In the isolated guinea pig ileum, several adenosine agonists and carbamazepine potently inhibited nicotine-stimulated and electrically stimulated contractions in a manner sensitive to the adenosine antagonist theophylline. High concentrations of carbamazepine were able to reduce the inhibition of electrically stimulated contractions by the adenosine agonist l-methylisoguanosine. The ability of theophylline to reduce the anticonvulsant efficacy of several drugs against pentylenetetrazole-induced seizures in mice was investigated. Theophylline pretreatment failed to alter anticonvulsant protection by trimethadione and sodium valproate, but significantly decreased the anticonvulsant effects of carbamazepine and phenobarbital. These results suggest that carbamazepine may exert some of its anti-convulsant effects by acting as a partial agonist at adenosine receptors.
在两个药理学系统中研究了卡马西平与腺苷受体的相互作用。在离体豚鼠回肠中，几种腺苷激动剂和卡马西平以对腺苷拮抗剂茶碱敏感的方式，强烈抑制尼古丁刺激和电刺激引起的收缩。高浓度的卡马西平能够降低腺苷激动剂l-甲基异鸟苷对电刺激收缩的抑制作用。研究了茶碱降低几种药物对小鼠戊四氮诱发惊厥的抗惊厥疗效的能力。茶碱预处理未能改变三甲双酮和丙戊酸钠的抗惊厥保护作用，但显著降低了卡马西平和苯巴比妥的抗惊厥作用。这些结果表明，卡马西平可能通过作为腺苷受体的部分激动剂发挥其部分抗惊厥作用。
