豚鼠肺动脉突触前β-肾上腺素能受体的进一步特性研究
Further characterization of presynaptic beta-adrenoceptors in guinea-pig pulmonary arteries.
作者信息
Misu Y, Kuwahara M, Kaiho M, Kubo T
出版信息
Eur J Pharmacol. 1983 Jul 22;91(2-3):287-90. doi: 10.1016/0014-2999(83)90480-6.
Presynaptic beta-adrenoceptors were further characterized in spiral strips of guinea-pig pulmonary arteries preloaded with [3H]norepinephrine. l-Metoprolol (3 X 10(-6) M) inhibited isoproterenol (3 X 10(-7) M)-induced increases in 3H efflux by transmural field stimulation, whereas the d-isomer produced no inhibition. However, IPS 339, H 35/25, butoxamine and metoprolol (3 X 10(-6) M) antagonized salbutamol (3 X 10(-7) M)-induced increases in the parameter, whereas acebutolol, bevantolol and practolol (3 X 10(-6) M) produced no antagonism. Presynaptic beta-adrenoceptors in guinea-pig pulmonary arteries appear to have characteristics similar to those postsynaptic classical beta-adrenoceptors.
在预先用[3H]去甲肾上腺素加载的豚鼠肺动脉螺旋条中，对突触前β-肾上腺素能受体进行了进一步的特性研究。左旋美托洛尔（3×10⁻⁶ M）可抑制异丙肾上腺素（3×10⁻⁷ M）通过跨壁场刺激诱导的3H外流增加，而右旋异构体则无抑制作用。然而，IPS 339、H 35/25、布托沙明和美托洛尔（3×10⁻⁶ M）可拮抗沙丁胺醇（3×10⁻⁷ M）诱导的该参数增加，而醋丁洛尔、贝凡洛尔和普拉洛尔（3×10⁻⁶ M）则无拮抗作用。豚鼠肺动脉中的突触前β-肾上腺素能受体似乎具有与突触后经典β-肾上腺素能受体相似的特性。
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