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耐力训练小鼠心肌中脯氨酰 4-羟化酶活性增加。

Increased prolyl 4-hydroxylase activity in the myocardium of endurance-trained mice.

作者信息

Kainulainen H, Takala T, Myllylä R, Hassinen I, Vihko V

出版信息

Experientia. 1983 Oct 15;39(10):1094-5. doi: 10.1007/BF01943125.

DOI:10.1007/BF01943125
PMID:6311607
Abstract

Endurance training over 3, 10 or 20 days increased the activity of prolyl 4-hydroxylase (PH) in the left ventricle of mice. No increase was observed in the weight of the left ventricle, in galactosylhydroxylysyl glucosyltransferase activity or in hydroxyproline concentration. The increase in PH suggests that the synthesis of collagen increases during physiological adaptation of the heart to endurance exercise without changes in the ventricle weight or its total collagen content.

摘要

持续3天、10天或20天的耐力训练增加了小鼠左心室中脯氨酰4-羟化酶(PH)的活性。在左心室重量、半乳糖基羟赖氨酰葡糖基转移酶活性或羟脯氨酸浓度方面未观察到增加。PH的增加表明,在心脏对耐力运动的生理适应过程中,胶原蛋白的合成增加,而心室重量或其总胶原蛋白含量没有变化。

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1
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2
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引用本文的文献

1
Increased activities of prolyl 4-hydroxylase and galactosylhydroxylysyl glucosyltransferase, enzymes of collagen biosynthesis, in skeletal muscle of endurance-trained mice.耐力训练小鼠骨骼肌中脯氨酰4-羟化酶和半乳糖基羟赖氨酰葡糖基转移酶(胶原蛋白生物合成酶)的活性增加。
Pflugers Arch. 1983 Dec;399(4):271-4. doi: 10.1007/BF00652751.
2
Effects of training and anabolic steroids on collagen synthesis in dog heart.
Eur J Appl Physiol Occup Physiol. 1991;62(1):1-6. doi: 10.1007/BF00635624.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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2
Collagen synthesis and content in right ventricular hypertrophy in the dog.犬右心室肥大时的胶原蛋白合成与含量
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Changes in the distribution of fibronectin and collagen during development of the neonatal rat heart.
Coll Relat Res. 1982;2(3):211-8. doi: 10.1016/s0174-173x(82)80015-0.
4
Collagen content in different areas of normal and hypertrophied rat myocardium.正常和肥厚大鼠心肌不同区域的胶原蛋白含量。
Cardiovasc Res. 1980 Sep;14(9):551-4. doi: 10.1093/cvr/14.9.551.
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Myocardial collagen in different forms of heart hypertrophy in the rat.大鼠不同形式心脏肥大中的心肌胶原
Res Exp Med (Berl). 1980;177(3):201-11. doi: 10.1007/BF01851210.
6
Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes.胶原蛋白生物合成中的翻译后修饰酶:细胞内酶
Methods Enzymol. 1982;82 Pt A:245-304. doi: 10.1016/0076-6879(82)82067-3.
7
Modifications of a specific assay for hydroxyproline in urine.尿中羟脯氨酸特定检测方法的改进。
Anal Biochem. 1967 May;19(2):249-55. doi: 10.1016/0003-2697(67)90160-1.
8
Modified procedure for the assay of H-3-or C-14-labeled hydroxyproline.H-3或C-14标记的羟脯氨酸测定的改良方法。
Anal Biochem. 1966 Apr;15(1):77-83. doi: 10.1016/0003-2697(66)90249-1.
9
Protocollagen proline hydroxylase activity in rat heart during experimental cardiac hypertrophy.实验性心肌肥大过程中大鼠心脏原胶原蛋白脯氨酸羟化酶活性
Circ Res. 1972 Feb;30(2):205-9. doi: 10.1161/01.res.30.2.205.
10
Biochemical correlates of cardiac hypertrophy. V. Labeling of collagen, myosin, and nuclear DNA during experimental myocardial hypertrophy in the rat.心脏肥大的生化关联。V. 大鼠实验性心肌肥大过程中胶原蛋白、肌球蛋白和核DNA的标记
Circ Res. 1972 Aug;31(2):145-57. doi: 10.1161/01.res.31.2.145.