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A synthetic peptide containing the autophosphorylation site of the transforming protein of Harvey sarcoma virus is phosphorylated by the EGF-stimulated tyrosine kinase.

作者信息

Baldwin G S, Stanley I J, Nice E C

出版信息

FEBS Lett. 1983 Mar 21;153(2):257-61. doi: 10.1016/0014-5793(83)80619-x.

DOI:10.1016/0014-5793(83)80619-x
PMID:6311615
Abstract

The transforming proteins (p21) of Harvey and Kirsten sarcoma viruses threonine kinase activity, which phosphorylates threonine 59 of the p21 proteins themselves. A tridecapeptide: Arg-Arg-Leu56-Asp-Thr-Thr59-Gly-Gln-Glu-Tyr-Ser-Ala66 containing residues 56-66 of p21 is phosphorylated solely on tyrosine by the epidermal growth factor (EGF)-stimulated tyrosine kinase of A431 cell membranes. Km-Values of 240 and 80 microM and Vmax values of 1.7 and 0.1 nmol.min-1.mg-1 were obtained in the presence and absence of EGF, respectively.

摘要

相似文献

1
A synthetic peptide containing the autophosphorylation site of the transforming protein of Harvey sarcoma virus is phosphorylated by the EGF-stimulated tyrosine kinase.
FEBS Lett. 1983 Mar 21;153(2):257-61. doi: 10.1016/0014-5793(83)80619-x.
2
Epidermal growth factor receptor metabolism and protein kinase activity in human A431 cells infected with Snyder-Theilen feline sarcoma virus or harvey or Kirsten murine sarcoma virus.感染斯奈德-泰伦猫肉瘤病毒、哈维或柯斯顿鼠肉瘤病毒的人A431细胞中表皮生长因子受体的代谢及蛋白激酶活性
J Virol. 1983 Dec;48(3):752-64. doi: 10.1128/JVI.48.3.752-764.1983.
3
Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes.
Proc Natl Acad Sci U S A. 1982 Mar;79(5):1443-7. doi: 10.1073/pnas.79.5.1443.
4
Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses.对哈维氏和克里斯滕氏鼠肉瘤病毒株编码的p21转化蛋白的磷酸化位点及周围氨基酸序列的表征。
J Biol Chem. 1982 Oct 10;257(19):11767-73.
5
Phosphorylation of gastrin-17 by epidermal growth factor-stimulated tyrosine kinase.表皮生长因子刺激的酪氨酸激酶对胃泌素-17的磷酸化作用。
Nature. 1983 Feb 3;301(5899):435-7. doi: 10.1038/301435a0.
6
Synthetic peptide substrates for the membrane tyrosine protein kinase stimulated by epidermal growth factor.
Eur J Biochem. 1984 Apr 16;140(2):363-7. doi: 10.1111/j.1432-1033.1984.tb08109.x.
7
Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine-containing peptide in a similar manner.转化生长因子和表皮生长因子以相似的方式刺激一种合成的含酪氨酸肽的磷酸化。
J Biol Chem. 1982 Dec 25;257(24):14628-31.
8
Phosphorylation of human growth hormone by the epidermal growth factor-stimulated tyrosine kinase.表皮生长因子刺激的酪氨酸激酶对人生长激素的磷酸化作用。
Proc Natl Acad Sci U S A. 1983 Sep;80(17):5276-80. doi: 10.1073/pnas.80.17.5276.
9
Synthetic peptide substrates for a tyrosine protein kinase.一种酪氨酸蛋白激酶的合成肽底物。
J Biol Chem. 1982 May 10;257(9):4843-8.
10
A cAMP-independent serine/threonine kinase activity is associated with the mos sequences of ts110 Moloney murine sarcoma virus-encoded P85gag-mos.一种不依赖环磷酸腺苷（cAMP）的丝氨酸/苏氨酸激酶活性与ts110莫洛尼氏鼠肉瘤病毒编码的P85gag-mos的mos序列相关。
J Gen Virol. 1985 Oct;66 ( Pt 10):2135-46. doi: 10.1099/0022-1317-66-10-2135.

引用本文的文献

1
In vitro substrate specificity of protein tyrosine kinases.蛋白质酪氨酸激酶的体外底物特异性
Mol Cell Biochem. 1993 Nov;127-128:103-12. doi: 10.1007/BF01076761.
2
Progesterone receptor subunits are high-affinity substrates for phosphorylation by epidermal growth factor receptor.孕酮受体亚基是表皮生长因子受体磷酸化的高亲和力底物。
Proc Natl Acad Sci U S A. 1984 Mar;81(6):1654-8. doi: 10.1073/pnas.81.6.1654.