神经递质导致的[3H]肌醇掺入磷脂酰肌醇从头合成与交换的增加。

Neurotransmitter-caused increase in [3H]inositol incorporation into phosphatidylinositol de novo synthesis vs exchange.

作者信息

Lupu M, Oron Y

出版信息

FEBS Lett. 1983 Oct 3;162(1):133-6. doi: 10.1016/0014-5793(83)81064-3.

DOI:10.1016/0014-5793(83)81064-3

Abstract

[3H]inositol and 32Pi were simultaneously incorporated into rat parotid phosphatidylinositol. The ratio of [3H]/32Pi incorporation dropped dramatically following stimulation with muscarinic or alpha-adrenergic agonists and returned to control values following the addition of appropriate antagonists. The drop in [3H]/32Pi ratio can be explained by a rapid increase in de- novo synthesis of phosphatidylinositol following its receptor-mediated breakdown. The change in this ratio also provided evidence for the existence of CDP-DG + inositol in equilibrium phosphatidylinositol exchange reaction in the intact tissue.

摘要

[3H]肌醇和32Pi同时掺入大鼠腮腺磷脂酰肌醇中。用毒蕈碱或α-肾上腺素能激动剂刺激后，[3H]/32Pi掺入率急剧下降，加入适当拮抗剂后恢复到对照值。[3H]/32Pi比率的下降可以通过磷脂酰肌醇受体介导的分解后从头合成的迅速增加来解释。该比率的变化也为完整组织中平衡的磷脂酰肌醇交换反应中存在CDP-DG+肌醇提供了证据。

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