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具有不同群抗原的轮状病毒的分子特征

Molecular characterization of rotaviruses with distinct group antigens.

作者信息

Pedley S, Bridger J C, Brown J F, McCrae M A

出版信息

J Gen Virol. 1983 Oct;64 (Pt 10):2093-101. doi: 10.1099/0022-1317-64-10-2093.

Abstract

Comparative serological and nucleic acid studies were carried out on rotavirus isolates, with and without the original group antigen. Indirect immunofluorescence allowed the atypical isolates to be divided into two groups each with its own distinct group antigen hence giving a total of at least three distinct rotavirus groups. Genome profile analysis of the atypical isolates again divided them into two groups which corresponded with those obtained by immunofluorescence and within which the overall pattern of genome segments was similar. A more rigorous examination of the degree of difference between the three virus groups was carried out using single-dimension terminal fingerprint analysis. This indicated that the viruses in the three groups did not carry any genome segments in common with each other. Therefore, experimental criteria have been established which allow the division of rotaviruses into three groups. Analysis of further atypical isolates, as they become available, will establish whether the division of rotaviruses into a number of separate groups, of the type seen in influenza virus, is justified.

摘要

对具有和不具有原始组抗原的轮状病毒分离株进行了血清学和核酸比较研究。间接免疫荧光法可将非典型分离株分为两组,每组都有其独特的组抗原,因此总共至少有三种不同的轮状病毒组。非典型分离株的基因组图谱分析再次将它们分为两组,这与通过免疫荧光获得的分组相对应,并且在这两组中基因组片段的总体模式相似。使用单维末端指纹分析对这三个病毒组之间的差异程度进行了更严格的检查。这表明这三组病毒彼此之间没有任何共同的基因组片段。因此,已经建立了实验标准,可将轮状病毒分为三组。随着更多非典型分离株的出现,对它们的分析将确定将轮状病毒分为若干个独立组(如流感病毒那样)是否合理。

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