Verna R, Nardi P, Muraro R, Delfini R, Frati L
J Neurosurg Sci. 1983 Apr-Jun;27(2):77-82.
The activity of total, Mg++ dependent and Na+/K+ ATPase as well as the content of cAMP and cGMP in homogenates of human brain tumors have been investigated. Results are compared to values obtained from normal cortices. Na+/K+ ATPase and cAMP are decreased with a close relationship with the degree of malignancy, while Mg++ dependent activity is lower than in normal cortex but with no differences between the various tumors, and cGMP is unaffected. We conclude with a discussion on the metabolism of brain tumors and the suggestion of Na+/K+ ATPase activity as a marker of the malignancy of neoplastic growth.
对人脑肿瘤匀浆中总ATP酶、镁离子依赖性ATP酶和钠钾ATP酶的活性以及环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的含量进行了研究。将结果与正常皮质获得的值进行比较。钠钾ATP酶和cAMP降低，且与恶性程度密切相关，而镁离子依赖性活性低于正常皮质，但不同肿瘤之间无差异，cGMP未受影响。我们通过对脑肿瘤代谢的讨论得出结论，并提出将钠钾ATP酶活性作为肿瘤生长恶性程度的标志物。
