Lestynek J L
Sem Hop. 1983 Sep 22;59(33):2354-7.
For many years the antidepressive or uninhibiting effect of sulpiride has been a subject of controversy. Following recent reports underscoring an antidepressive action of sulpiride with mood inversion, we have studied 17 patients with depression in order to build a personal opinion. With a daily dosage of 150 mg, a satisfactory response was recorded in overall pathology in 76.5% of cases, and in depressive manifestations in 82% of cases. Therefore, we believe that sulpiride does have an antidepressive action, which begins approximately on the tenth day of treatment, while the uninhibiting effect becomes noticeable on the fifth day. It is to be pointed out that, among the 12 patients who had failed to respond to prior therapy with tricyclic antidepressants, 10 responded very satisfactorily to sulpiride.
多年来，舒必利的抗抑郁或解除抑制作用一直存在争议。随着近期有报告强调舒必利具有情绪反转的抗抑郁作用，我们对17例抑郁症患者进行了研究，以形成个人观点。每日剂量为150毫克时，76.5%的病例在整体病情上有满意反应，82%的病例在抑郁表现上有满意反应。因此，我们认为舒必利确实具有抗抑郁作用，大约在治疗的第十天开始起效，而解除抑制作用在第五天就会显现。需要指出的是，在之前使用三环类抗抑郁药治疗无效的12例患者中，有10例对舒必利反应非常满意。
