Nazarenko V I, Pastukhova T E, Belik Ia V
Ukr Biokhim Zh (1978). 1983 Jul-Aug;55(4):398-402.
The effect of ethonium, a local anesthetic, on the membrane preparations of brain N+, K+-ATPase was studied by fluorescent, radioisotopic, electron-microscopic and electrophysiological methods. Ethonium is established to affect the formation of an intermediate phosphorylated product and has no pronounced destructive effect on the membrane. It changes the fluorescence intensity of 2-toluidinonaphthalen-6-sulphonate (TNS), astrafloxin (AF) and fluorene probes in a suspension of the Na+, K+-ATPase preparations, which evidences for ethonium-induced changes in the structure of membrane fragments.
采用荧光、放射性同位素、电子显微镜和电生理方法，研究了局部麻醉药乙胺对脑N⁺、K⁺-ATP酶膜制剂的影响。已证实乙胺会影响中间磷酸化产物的形成，且对膜无明显破坏作用。它会改变Na⁺、K⁺-ATP酶制剂悬浮液中2-甲苯胺萘-6-磺酸盐（TNS）、阿斯特罗毒素（AF）和芴探针的荧光强度，这证明乙胺会引起膜片段结构的变化。
