Murray K H
Urology. 1983 Sep;22(3):329-31. doi: 10.1016/s0090-4295(83)80032-6.
The effects of opioid blockade with the potent opiate/opioid antagonist, naloxone, on detrusor function are described. In a double-blind placebo-controlled trial of 28 patients, naloxone caused an increase in detrusor instability together with an increase of detrusor pressure during filling cystometry and a decrease in maximum cystometric capacity. The significance of these findings for the etiology of idiopathic detrusor instability is discussed.
描述了强效阿片类/阿片受体拮抗剂纳洛酮进行阿片类阻断对逼尿肌功能的影响。在一项针对28名患者的双盲安慰剂对照试验中，纳洛酮导致逼尿肌不稳定增加，同时在膀胱测压充盈期间逼尿肌压力升高，最大膀胱测压容量降低。讨论了这些发现对特发性逼尿肌不稳定病因的意义。
