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去甲肾上腺素在铁诱导的大鼠致痫性大脑皮层中引发环磷酸腺苷积累

Elicitation of cyclic AMP accumulation by norepinephrine in the iron-induced epileptogenic cerebral cortex of rats.

作者信息

Hattori Y, Moriwaki A, Yasuhara H, Nishida N, Hori Y

出版信息

Acta Med Okayama. 1983 Aug;37(4):377-80. doi: 10.18926/AMO/32391.

DOI:10.18926/AMO/32391
PMID:6312769
Abstract

A microinjection of ferric chloride solution into the left frontal cortex of rats induced epileptic discharges which were recorded by electrocorticography. In animals having such electrographic seizure activity 30 to 60 days after the injection, the accumulation of cyclic AMP elicited by norepinephrine was examined in slices from four cortical regions. The accumulation was significantly greater in the left anterior area, into which region the ferric chloride solution was injected, than in the right anterior area. There was also a tendency for greater norepinephrine-elicited accumulation of cyclic AMP to occur in the left posterior area than in the right posterior area.

摘要

向大鼠左额叶皮质微量注射氯化铁溶液可诱发癫痫放电,通过皮质脑电图进行记录。在注射后30至60天具有这种脑电图癫痫活动的动物中,检测了来自四个皮质区域切片中去甲肾上腺素引发的环磷酸腺苷(cAMP)积累情况。在注射氯化铁溶液的左前区,cAMP的积累明显大于右前区。左后区去甲肾上腺素引发的cAMP积累也有高于右后区的趋势。

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