对已知5-硝基咪唑衍生物和CG 10213-Go在金黄仓鼠（Mesocricetus auratus）体内的杀阿米巴活性进行比较研究，这些金黄仓鼠的肝脏或盲肠或两者均被溶组织内阿米巴滋养体感染。
Comparative studies on the amoebicidal activity of known 5-nitroimidazole derivatives and CG 10213-Go in golden hamsters, Mesocricetus auratus, infected in the liver or caecum or both with trophozoites of Entamoeba histolytica.
作者信息
Ray D K, Shrivastava V B, Tendulkar J S, Dutta A K, Bhopale K K, Chatterjee D K, Nagarajan K
出版信息
Ann Trop Med Parasitol. 1983 Jun;77(3):287-91. doi: 10.1080/00034983.1983.11811709.
Abstract
CG 10213-Go, a 5-nitroimidazole derivative synthesized at the CIBA-Geigy Research Centre, Bombay, proved superior to such currently used 5-nitroimidazole derivatives as metronidazole, ornidazole, secnidazole, tinidazole and nimorazole, against experimental amoebic infections of the liver and caecum in a golden hamster model. CG 10213-Go is now undergoing clinical trials.
摘要
CG 10213-Go是一种在孟买的汽巴-嘉基研究中心合成的5-硝基咪唑衍生物，在金黄仓鼠模型中，它对肝脏和盲肠的实验性阿米巴感染的治疗效果优于目前使用的5-硝基咪唑衍生物，如甲硝唑、奥硝唑、塞克硝唑、替硝唑和尼莫唑。CG 10213-Go目前正在进行临床试验。
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