猴空泡病毒40的转化遗传学
The genetics of transformation by SV 40.
作者信息
Feunteun J, Petit C A
出版信息
Arch Geschwulstforsch. 1983;53(4):301-2.
PMID:6312919
Abstract
Experiments using the tsA 58 allele of the SV 40-A gene have demonstrated that the SV 40 large T-antigen is strictly required both for immortalization and induction anchorage independence of cells. It has been suggested that the immortalized phenotype is mediated by an extra cellular factor. The synthesis and/or the excretion of this factor in a medium is controlled by the A gene.
摘要
使用SV 40 - A基因的tsA 58等位基因进行的实验表明，SV 40大T抗原对于细胞永生化和诱导细胞锚定非依赖性都是绝对必需的。有人提出，永生化表型是由一种细胞外因子介导的。该因子在培养基中的合成和/或分泌受A基因控制。
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