Banerjee R B, Bhadra R, Datta A G
Biochem Biophys Res Commun. 1983 Sep 15;115(2):506-11. doi: 10.1016/s0006-291x(83)80173-9.
Alanine-2-oxoglutarate aminotransferase activity in mouse liver is stimulated by the intravenous injection of glucagon. The stimulation is abolished by pretreatment with actinomycin D indicating that the increased activity is probably due to new enzyme formation. Administration of dibutyryl cyclic AMP, isoproterenol, an activator of adenyl cyclase and theophylline, an inhibitor of phosphodiesterase also increases the enzyme activity suggesting the involvement of cyclic AMP in glucagon-mediated increase of enzyme activity.
静脉注射胰高血糖素可刺激小鼠肝脏中的丙氨酸 - 2 - 酮戊二酸转氨酶活性。放线菌素D预处理可消除这种刺激，这表明活性增加可能是由于新酶的形成。给予二丁酰环磷腺苷、异丙肾上腺素（一种腺苷酸环化酶激活剂）和茶碱（一种磷酸二酯酶抑制剂）也会增加该酶的活性，这表明环磷腺苷参与了胰高血糖素介导的酶活性增加过程。
