阿片类药物对离散脑区急性增强的去甲肾上腺素释放的差异性修饰作用。
Differential modification by opioid agents of acutely enhanced noradrenaline release in discrete brain regions.
作者信息
Kohno Y, Tanaka M, Hoaki Y, Ida Y, Nagasaki N
出版信息
Eur J Pharmacol. 1983 Sep 2;92(3-4):265-8. doi: 10.1016/0014-2999(83)90296-0.
PMID:6313396
Abstract
Although immobilization stress-induced increases in MHPG-SO4 level in the hypothalamus, amygdala and thalamus were enhanced by naloxone and attenuated by morphine, both agents failed to exert significant effects upon regional MHPG-SO4 levels in methamphetamine-treated rats. The results indicate that there is a differential modification by opioid agents of acutely enhanced noradrenaline release induced by physiological and by pharmacological manipulations.
摘要
尽管纳洛酮增强了固定应激诱导的下丘脑、杏仁核和丘脑内3-甲氧基-4-羟基苯乙二醇硫酸酯（MHPG-SO4）水平的升高，而吗啡则使其减弱，但这两种药物对甲基苯丙胺处理的大鼠的局部MHPG-SO4水平均未产生显著影响。结果表明，阿片类药物对生理和药理操作诱导的急性去甲肾上腺素释放增强有不同的调节作用。
相似文献
1
Differential modification by opioid agents of acutely enhanced noradrenaline release in discrete brain regions.阿片类药物对离散脑区急性增强的去甲肾上腺素释放的差异性修饰作用。
Eur J Pharmacol. 1983 Sep 2;92(3-4):265-8. doi: 10.1016/0014-2999(83)90296-0.
2
Psychological stress-induced increases in noradrenaline release in rat brain regions are attenuated by diazepam, but not by morphine.
Pharmacol Biochem Behav. 1991 May;39(1):191-5. doi: 10.1016/0091-3057(91)90420-7.
3
Effects of neurotropin on regional brain noradrenaline metabolism in rats.
Jpn J Pharmacol. 1989 Feb;49(2):187-96. doi: 10.1254/jjp.49.187.
4
Regional characteristics of stress-induced increases in brain noradrenaline release in rats.
Pharmacol Biochem Behav. 1983 Sep;19(3):543-7. doi: 10.1016/0091-3057(83)90132-6.
5
Naloxone, given before but not after stress exposure, enhances stress-induced increases in regional brain noradrenaline release.
Pharmacol Biochem Behav. 1988 Mar;29(3):613-6. doi: 10.1016/0091-3057(88)90028-7.
6
[Regional characteristics of noradrenaline turnover as reflected in the brain levels of MHPG-SO4].
Nihon Yakurigaku Zasshi. 1983 Mar;81(3):175-92.
7
Naloxone enhances stress-induced increases in noradrenaline turnover in specific brain regions in rats.
Life Sci. 1982 May 10;30(19):1663-9. doi: 10.1016/0024-3205(82)90499-4.
8
Differential effects of morphine on noradrenaline release in brain regions of stressed and non-stressed rats.
Brain Res. 1983 Sep 19;275(1):105-15. doi: 10.1016/0006-8993(83)90422-5.
9
Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates.血浆和脑脊液中3-甲氧基-4-羟基苯乙二醇（MHPG）作为灵长类动物脑去甲肾上腺素代谢指标
Brain Res. 1982 Mar 4;235(1):115-24. doi: 10.1016/0006-8993(82)90200-1.
10
Pentobarbital attenuates stress-induced increases in noradrenaline release in specific brain regions of rats.
Pharmacol Biochem Behav. 1990 Aug;36(4):953-6. doi: 10.1016/0091-3057(90)90105-q.
引用本文的文献
1
Progesterone increased β-endorphin innervation of the locus coeruleus, but ovarian steroids had no effect on noradrenergic neurodegeneration.孕酮增加了蓝斑核的β-内啡肽神经支配，但卵巢类固醇对去甲肾上腺素能神经变性没有影响。
Brain Res. 2017 May 15;1663:1-8. doi: 10.1016/j.brainres.2017.03.008. Epub 2017 Mar 8.
Zotero 插件