von Krogh G, Maibach H I
Dermatologica. 1983;167(2):70-7.
Four lignans: podophyllotoxin (A), 4'-demethyl-podophyllotoxin (B), alpha-peltatin (C), and beta-peltatin (D) are the podophyllin ingredients producing lesional necrosis after application on condylomata acuminata. This study evaluates comparatively their destructive potency on rabbit skin after 10-day repeated applications. Any visible changes or increase on skinfold thickness induced by each of the drugs tested as 0.01, 0.05, 0.1, and 0.5% ethanolic preparations were followed. These variables demonstrated a close covariation; the analyses revealed a significant difference with respect to influence on measurements according to the following ranking order: A greater than C greater than D = B.
鬼臼毒素（A）、4'-去甲基鬼臼毒素（B）、α-盾叶鬼臼素（C）和β-盾叶鬼臼素（D）是在尖锐湿疣上应用后产生病灶坏死的鬼臼树脂成分。本研究比较了它们在连续应用10天后对兔皮肤的破坏效力。观察了作为0.01%、0.05%、0.1%和0.5%乙醇制剂测试的每种药物引起的任何可见变化或皮褶厚度增加。这些变量显示出密切的共变关系；分析表明，根据以下排序顺序，对测量结果的影响存在显著差异：A大于C大于D = B。
