Degli Uberti E C, Trasforini G, Salvadori S, Margutti A, Tomatis R, Bianconi M, Rotola C, Pansini R
J Clin Endocrinol Metab. 1983 Dec;57(6):1179-85. doi: 10.1210/jcem-57-6-1179.
This study was designed to investigate the effect of dermorphin (D), a new synthetic potent opiate-like peptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), on PRA, plasma aldosterone (PA), plasma cortisol (PC), and plasma ACTH levels in normal men. D infusion (5.5 micrograms/kg X min for 30 min) significantly increased PRA (P less than 0.01) and decreased PC levels (P less than 0.02). D produced a small decrease in ACTH and a small increase in PA. Pretreatment with the opioid receptor antagonist naloxone (N) blunted the D-induced PRA increase and completely prevented the D-induced PC decrease, but enhanced PC and ACTH levels. These data indicate that the action of D is mediated through opioid receptors, and are consistent with the conclusion that 1) D, a new opioid peptide, increases PRA levels, perhaps via activation of the sympathetic nervous system, providing evidence that opioid peptides may exert an influence on renin secretion; and 2) D suppresses PC levels, perhaps by affecting ACTH secretion, corroborating previous observations that opioid peptides might affect the function of the pituitary-adrenocortical axis.
本研究旨在探讨一种新的合成强效阿片样肽（H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2）——皮啡肽（D）对正常男性血浆肾素活性（PRA）、血浆醛固酮（PA）、血浆皮质醇（PC）和血浆促肾上腺皮质激素（ACTH）水平的影响。静脉输注D（5.5微克/千克×分钟，持续30分钟）可显著升高PRA（P<0.01）并降低PC水平（P<0.02）。D可使ACTH略有下降，PA略有升高。用阿片受体拮抗剂纳洛酮（N）预处理可减弱D诱导的PRA升高，并完全阻止D诱导的PC降低，但可提高PC和ACTH水平。这些数据表明，D的作用是通过阿片受体介导的，并且与以下结论一致：1）一种新的阿片肽D可能通过激活交感神经系统来升高PRA水平，这为阿片肽可能对肾素分泌产生影响提供了证据；2）D可能通过影响ACTH分泌来抑制PC水平，这证实了先前的观察结果，即阿片肽可能影响垂体-肾上腺皮质轴的功能。
