Pandya S S, Naik S S, Gurnani S
Lepr India. 1983 Apr;55(2):237-41.
The effect of the contents of activated macrophages on the degenerative/regenerative process in the mouse sciatic nerve was investigated as a possible model for leprosy. The whole cellular homogenate or saline was injected every week around physically impaired (to bypass the perineurial barrier) and normal nerves. Recovery of the nerve function was monitored clinically and electromyographically. After 14 weeks animals were sacrificed and nerves were processed for histology. The data obtained from 134 experimental and control nerves were rated and analysed statistically. The course of the nerve regeneration in the physically impaired nerve with and without homogenate was found to be similar. One of the reasons for this could be insufficient concentration of the homogenate in the endoneurial space.
作为麻风病的一种可能模型，研究了活化巨噬细胞的含量对小鼠坐骨神经退变/再生过程的影响。每周将全细胞匀浆或生理盐水注射到物理损伤（绕过神经束膜屏障）的神经和正常神经周围。通过临床和肌电图监测神经功能的恢复情况。14周后处死动物，对神经进行组织学处理。对从134条实验神经和对照神经获得的数据进行评分并进行统计学分析。发现有和没有匀浆的物理损伤神经中的神经再生过程相似。其原因之一可能是神经内膜间隙中匀浆的浓度不足。
