Auriac A, Azam J, Dumas J C, Roux G, Montastruc J L
J Pharmacol. 1983 Jul-Sep;14(3):351-60.
The effects of phenylephrine (alpha 1 +) and prazosin (alpha 1 -) on water intake, diuresis, food intake and blood pressure were compared in conscious normal and diabetic insipidus (DI) Long Evans rats. The two drugs did not change the values measured on 24 hours in the two groups of animals (tables I and II). Phenylephrine induced a diuretic response in both normal and DI rats during the two first hours. Water intake was decreased in normal rats and increased in DI animals (fig. 1). Prazosin induced an antidiuretic effect in the two groups of animals, an increase in water intake in normal rats and a decrease in water intake in DI animals (fig. 2). Blood pressure was not changed in the two groups of animals two hours after injection. The comparison between the different results shows that the first changes induced by phenylephrine or prazosin were changes in diuresis. Since the two drugs act in a same way on the diuresis of normal and vasopressin--deprived rats, it is concluded that the neurohypophysial peptide is not involved in the variations of urinary volume induced by the alpha 1-adrenergic drugs.
在清醒的正常和尿崩症（DI）长 Evans 大鼠中，比较了去氧肾上腺素（α1 +）和哌唑嗪（α1 -）对水摄入、利尿、食物摄入和血压的影响。这两种药物在两组动物中均未改变 24 小时所测值（表 I 和表 II）。在最初两小时内，去氧肾上腺素在正常大鼠和 DI 大鼠中均诱导出利尿反应。正常大鼠的水摄入量减少，而 DI 动物的水摄入量增加（图 1）。哌唑嗪在两组动物中均诱导出抗利尿作用，正常大鼠的水摄入量增加，而 DI 动物的水摄入量减少（图 2）。注射两小时后，两组动物的血压均未改变。不同结果之间的比较表明，去氧肾上腺素或哌唑嗪诱导的最初变化是利尿方面的变化。由于这两种药物对正常大鼠和去血管升压素大鼠的利尿作用方式相同，因此得出结论，神经垂体肽不参与由α1 -肾上腺素能药物引起的尿量变化。
