Forrest W A
J Int Med Res. 1978;6(2):136-40. doi: 10.1177/030006057800600212.
One hundred and two patients with essential hypertension, managed in hospital out-patient clinics in the United Kingdom on a drug regime of beta-receptor antagonist alone, or in combination with a diuretic were successfully transferred to once daily sustained release oxprenolol. Where a diuretic was prescribed the dose remained unchanged. Improved control of blood pressure was recorded in the majority of patients with one or two morning tablets of sustained release oxprenolol. Preference for once daily therapy, enthusiasm for the calendar pack, and a net increase in the mean daily dosage of a beta-receptor antagonist were the probable factors contributing to the improvement recorded. Once daily sustained release oxprenolol would appear, in most hypertensive patients, to be an effective substitute for multi-dose treatment with beta-receptor antagonists in conventional formulation.
102例原发性高血压患者在英国医院门诊接受治疗，他们原本单独使用β受体拮抗剂或与利尿剂联合使用药物治疗，现成功转换为每日一次的缓释氧烯洛尔治疗。若之前已开具利尿剂，其剂量保持不变。大多数患者服用一或两片晨起缓释氧烯洛尔后，血压控制得到改善。每日一次治疗的便利性、对日历包装的青睐以及β受体拮抗剂平均日剂量的净增加可能是导致记录到的改善的因素。在大多数高血压患者中，每日一次的缓释氧烯洛尔似乎是传统剂型β受体拮抗剂多剂量治疗的有效替代方案。
