Wagner G P, Oertel W H, Wolff J R
Neurosci Lett. 1983 Sep 9;39(3):255-60. doi: 10.1016/0304-3940(83)90309-9.
In intact dentate gyrus, glutamate decarboxylase immunoreactivity (GAD) and cytochrome oxidase activity (CyO) showed different distributions patterns. Entorhinal lesions caused increases of GAD and CyO in the outer molecular layer (OML) of the ipsilateral side. Submicroscopical localization of these enzymes did not change, except for CyO labeling more astrocytic mitochondria. The increase in numerical density of GAD puncta correlated quantitatively with shrinkage of OML, whereas in the whole molecular layer the number of GAD puncta remained unchanged. Hence, the localized increase of enzyme activities and lysosomes is apparently related to shrinkage of OML, but does not indicate plasticity of GABAergic neurons.
在完整的齿状回中，谷氨酸脱羧酶免疫反应性（GAD）和细胞色素氧化酶活性（CyO）呈现出不同的分布模式。内嗅皮层损伤导致同侧外分子层（OML）中GAD和CyO增加。除了CyO标记更多星形胶质细胞线粒体外，这些酶的亚显微镜定位没有改变。GAD斑点的数值密度增加与OML的收缩在数量上相关，而在整个分子层中GAD斑点的数量保持不变。因此，酶活性和溶酶体的局部增加显然与OML的收缩有关，但并不表明GABA能神经元的可塑性。
