Goldowitz D, Vincent S R, Wu J Y, Hökfelt T
Brain Res. 1982 Apr 29;238(2):413-20. doi: 10.1016/0006-8993(82)90116-0.
The distribution of GABA fibers within the dentate gyrus was immunohistochemically examined following lesions of the entorhinal cortex in the adult rat. A major change in the pattern of the GAD immunoreactive fibers within the molecular layer, characterized by a marked increase in the density of fibers in the outer molecular layer, was observed. This change in the lamination of the dentate GABA fibers following entorhinal lesions appeared very similar to the changes which occur in acetylcholinesterase staining following entorhinal denervation of the dentate. These results provide morphological support for the sprouting of GABA fibers in the dentate gyrus in response to perforant path destruction.
在成年大鼠内嗅皮层损伤后，采用免疫组织化学方法检查了齿状回内GABA纤维的分布。观察到分子层内GAD免疫反应性纤维模式的一个主要变化，其特征是外分子层纤维密度显著增加。内嗅皮层损伤后齿状回GABA纤维分层的这种变化，与齿状回内嗅去神经支配后乙酰胆碱酯酶染色所发生的变化非常相似。这些结果为齿状回中GABA纤维响应穿通通路破坏而发生的发芽提供了形态学支持。
