Hansen S, Larsson K, Carlsson S G, Sourander P
Dev Psychobiol. 1978 Jan;11(1):51-61. doi: 10.1002/dev.420110109.
Rats were subjected to pre- and postnatal undernutrition by restricting the food intake of their mothers (U); another group of rats was normally fed (N). Each nutrition group was divided into 3 subgroups by varying the degree of environmental stimulation: animals in the Max group were stimulated by handling and enriched rearing conditions; the Min group rats were subjected to social isolation; rats in the control condition (C) were raised under ordinary laboratory conditions. The onset of sexual activity was not affected in the U-C male rats, but was delayed in both U-Min and N-Min rats. Although no difference existed in the age of puberty between the N-Max and N-C animals, the U-Max rats displayed an advancement of puberty by 7 days in comparison to the U-C rats. Undernutrition did not affect female sexual maturation; however the Max condition delayed this process in both nutrition groups.
通过限制母鼠的食物摄入量，使大鼠在出生前和出生后处于营养不足状态（U组）；另一组大鼠正常喂养（N组）。每个营养组根据环境刺激程度分为3个亚组：Max组的动物通过触摸和丰富的饲养条件进行刺激；Min组的大鼠进行社会隔离；处于对照条件（C组）的大鼠在普通实验室条件下饲养。U-C组雄性大鼠的性活动开始时间未受影响，但U-Min组和N-Min组大鼠的性活动开始时间均延迟。虽然N-Max组和N-C组动物的青春期年龄没有差异，但与U-C组大鼠相比，U-Max组大鼠的青春期提前了7天。营养不足并未影响雌性大鼠的性成熟；然而，Max条件在两个营养组中均延迟了这一过程。
