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[肝硬化患者耶尔森菌感染的血清学诊断。针对73例患者的研究]

[Serodiagnosis of Yersinia infections in cirrhotic patients. Study apropos of 73 patients].

作者信息

Grivaux M, Pieron R, Vergez P

出版信息

Sem Hop. 1983 Oct 6;59(35):2441-5.

PMID:6314524
Abstract

It is well-known that cirrhosis is a predisposing factor to Yersinia septicemia. This study includes 73 cirrhotics and shows a high number of positive serologic tests (47/73 : 64.4%). However, there is no correlation with clinical features or bacteriological findings. The most frequent serotypes, i.e. pseudotuberculosis IV and enterocolitica 0:9, differ from those which are usually found in Yersinia septicemias. Iron overload in cirrhosis, increased intestinal load of gram-negative bacilli and possible latent bacteremia may partly explain these results. However, the role probably played by as yet poorly known cross-reactions between Yersinia and other pathogens (Shigella, E. Coli...) must be underscored. The authors conclude that slightly positive, stable, serodiagnostic tests have little meaning in cirrhotics.

摘要

众所周知,肝硬化是耶尔森菌败血症的一个诱发因素。本研究纳入了73例肝硬化患者,结果显示血清学检测阳性率很高(47/73:64.4%)。然而,这与临床特征或细菌学检查结果并无关联。最常见的血清型,即假结核耶尔森菌IV型和小肠结肠炎耶尔森菌0:9型,与通常在耶尔森菌败血症中发现的血清型不同。肝硬化中的铁过载、革兰氏阴性杆菌肠道负荷增加以及可能存在的潜在菌血症可能部分解释了这些结果。然而,必须强调耶尔森菌与其他病原体(志贺菌、大肠杆菌等)之间尚不明确的交叉反应可能发挥的作用。作者得出结论,血清学诊断试验呈弱阳性且结果稳定,这对肝硬化患者意义不大。

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