Comparative susceptibility of the agents of adiaspiromycosis to imidazole derivatives in vitro.

Clotrimazole, econazole, ketoconazole and miconazole inhibited the growth of Emmonsia crescens and E. parva in vitro. Clotrimazole and econazole gave particularly low minimal inhibitory concentrations against the mycelial phase of the fungi, and minimal fungicidal concentrations of all four antifungals were about 2 to 4 times higher than the minimal inhibitory concentration. The adiasporic developmental phases of E. crescens and E. parva were slightly more sensitive to all the imidazole antifungals than the mycelial phases.