Chen T S, Ando M
Toxicol Appl Pharmacol. 1983 Sep 30;70(3):494-6. doi: 10.1016/0041-008x(83)90167-9.
The purpose of this study was to investigate the protective effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) on whole-body irradiation-induced inhibition of intestinal transport function. The jejunal transport of fluid and sugars was studied in male Swiss-Webster mice before and 3 days after whole-body irradiation (1000 rads). The rates of glucose and water transport were decreased by 86 and 70%, respectively, in irradiated animals. However, the rate of transport of 3-O-methyl-D-glucose (3MG) was not affected. In mice receiving WR-2721 (500 mg/kg, ip) 15 to 30 min prior to whole-body irradiation, net water flux was unaffected and the rate of D-glucose transport was decreased only 8%. WR-2721 administered alone (500 mg/kg, ip) had no effect on either D-glucose transport or net water flux across the jejunal mucosa. The results suggest that WR-2721 protects against irradiation-induced inhibition of some intestinal transport functions.
本研究的目的是探讨S-2-(3-氨丙基氨基)乙基硫代磷酸（WR-2721）对全身照射所致肠道转运功能抑制的保护作用。在雄性瑞士-韦伯斯特小鼠全身照射（1000拉德）前及照射后3天，研究空肠对液体和糖类的转运。照射动物的葡萄糖和水转运速率分别降低了86%和70%。然而，3-O-甲基-D-葡萄糖（3MG）的转运速率未受影响。在全身照射前15至30分钟接受WR-2721（500毫克/千克，腹腔注射）的小鼠中，净水流未受影响，D-葡萄糖转运速率仅降低了8%。单独给予WR-2721（500毫克/千克，腹腔注射）对空肠黏膜的D-葡萄糖转运或净水流均无影响。结果表明，WR-2721可防止照射引起的某些肠道转运功能抑制。
