Hirano-bodies in the distal symmetric polyneuropathy of the spontaneously diabetic BB-Wistar rat.

Lattice-like cytoplasmic inclusions have been demonstrated in a variety of pathologic conditions of the CNS and PNS in both man and animals. We describe 2 types of such inclusions occurring in association with the distal central-peripheral symmetric polyneuropathy of the spontaneously diabetic BB-Wistar rat. In the literature, both these lattice-like inclusions have been referred to as Hirano-bodies, but have not been separated on the basis of different measurements, locations or possible origins.