Raff H, Shinsako J, Keil L C, Dallman M F
Am J Physiol. 1983 Nov;245(5 Pt 1):E489-93. doi: 10.1152/ajpendo.1983.245.5.E489.
We decreased arterial PO2 at three different rates and measured blood pressure (BP), vasopressin (AVP), ACTH, and corticosteroid levels in nonsurgically stressed, anesthetized, paralyzed dogs. PaO2 was lowered to 28 Torr in 2 (fast), 10 (moderate), and 20 min (slow). The fast dPO2/dt produced a large spike in BP. Increases in AVP, ACTH, and corticosteroids were similar regardless of the dPO2/dt. When the spike in BP during the fast dPO2/dt was prevented with nitroprusside, hormone levels increased more quickly and were higher during the first 20-30 min of hypoxia. By 60 min, hormone levels were not different between experiments. The data suggest that 1) faster decreases in PO2 produce larger increases in BP, 2) increases in AVP, ACTH, and corticosteroids are primarily sensitive to the level of steady-state PaO2, and 3) increases in BP inhibit stress-induced increases in AVP and ACTH.
我们以三种不同速率降低动脉血氧分压（PO2），并测量了非手术应激、麻醉、麻痹犬的血压（BP）、血管加压素（AVP）、促肾上腺皮质激素（ACTH）和皮质类固醇水平。将动脉血氧分压分别在2分钟（快速）、10分钟（中度）和20分钟（缓慢）内降至28托。快速的dPO2/dt导致血压大幅飙升。无论dPO2/dt如何，AVP、ACTH和皮质类固醇的增加情况相似。当用硝普钠阻止快速dPO2/dt期间的血压飙升时，激素水平升高得更快，并且在缺氧的前20 - 30分钟内更高。到60分钟时，各实验之间的激素水平没有差异。数据表明：1）PO2更快降低会使血压升高幅度更大；2）AVP、ACTH和皮质类固醇的增加主要对稳态动脉血氧分压水平敏感；3）血压升高会抑制应激诱导的AVP和ACTH增加。
