Mehta A K, Kulkarni S K
Arch Int Pharmacodyn Ther. 1983 Aug;264(2):180-6.
Effect of adenosine, 2-chloroadenosine (P1-purinoceptor agonists) and adenosine triphosphate (ATP), adenosine-5'-tetraphosphate (P2-purinoceptor agonists) on body temperature was studied in mice. Adenosine (7.5-200 mg/kg) as well as 2-chloroadenosine (0.25-7.5 mg/kg) induced hypothermia in a dose-dependent manner. However, ATP or adenosine-5'-tetraphosphate did not show any effect on body temperature. Caffeine and theophylline, P1-purinoceptor antagonists, blocked the hypothermic response of adenosine and 2-chloroadenosine. Treatment with quinidine or phenoxybenzamine (non-specific P2-purinoceptor antagonists) did not modify the hypothermic response. Similarly, treatment with drugs which modify adrenergic (reserpine, propranolol, labetalol or haloperidol), serotonergic (cyproheptadine) or histaminergic functions failed to block adenosine or 2-chloroadenosine-induced hypothermia. These results demonstrated that P1-purinoceptors mediated the hypothermic response of these purines.
研究了腺苷、2-氯腺苷（P1嘌呤受体激动剂）以及三磷酸腺苷（ATP）、腺苷-5'-四磷酸（P2嘌呤受体激动剂）对小鼠体温的影响。腺苷（7.5 - 200毫克/千克）以及2-氯腺苷（0.25 - 7.5毫克/千克）以剂量依赖的方式诱导体温过低。然而，ATP或腺苷-5'-四磷酸对体温没有任何影响。P1嘌呤受体拮抗剂咖啡因和茶碱阻断了腺苷和2-氯腺苷的体温过低反应。用奎尼丁或苯氧苄胺（非特异性P2嘌呤受体拮抗剂）处理并没有改变体温过低反应。同样，用改变肾上腺素能（利血平、普萘洛尔、拉贝洛尔或氟哌啶醇）、5-羟色胺能（赛庚啶）或组胺能功能的药物处理也未能阻断腺苷或2-氯腺苷诱导的体温过低。这些结果表明，P1嘌呤受体介导了这些嘌呤的体温过低反应。
