晶状体钙激活蛋白酶：波形蛋白的降解
Lens calcium activated proteinase: degradation of vimentin.
作者信息
Roy D, Chiesa R, Spector A
出版信息
Biochem Biophys Res Commun. 1983 Oct 14;116(1):204-9. doi: 10.1016/0006-291x(83)90401-1.
PMID:6315001
Abstract
The lens has been shown to contain a Ca+2 activated proteinase specific for vimentin. The proteinase is present in the soluble fraction of the cortex but not in the epithelium. It is suggested that this proteinase is expressed during terminal differentiation of the epithelial cells and may be responsible for degradation of the intermediate filaments in the fiber cells. The proteinase is inhibited by EGTA but not by several proteinase inhibitors.
摘要
晶状体已被证明含有一种对波形蛋白具有特异性的Ca+2激活蛋白酶。该蛋白酶存在于皮质的可溶部分，而上皮中不存在。有人认为这种蛋白酶在上皮细胞的终末分化过程中表达，可能负责纤维细胞中中间丝的降解。该蛋白酶可被乙二醇双四乙酸（EGTA）抑制，但不受几种蛋白酶抑制剂的抑制。
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