Tarakhovskiĭ A M, Zhmareva E N, Romodanov S A
Biull Eksp Biol Med. 1983 Nov;96(11):86-8.
The intensity of formation of superoxide radicals (O(-2)) and superoxide dismutase (SOD) activity in the tissue of two transplantable gliomas were examined. The cells of these tumors were marked by unbalance between the intensity of O(-2) formation by nuclear membranes and their detoxication of SOD. This unbalance was particularly demonstrable in glioma 35 which was marked by rapid growth and high sensitivity to adriamycin. Slow-growing glioma was noted for higher activity of SOD and was insensitive to adriamycin. Since it is known that anthracycline antibiotics raise the intensity of the formation of free oxygen radicals in tumor cells, the data obtained suggest that the intensity of formation and detoxication of O(-2) may be used for the assessment of the sensitivity to these drugs.
检测了两种可移植性胶质瘤组织中超氧阴离子自由基（O(-2)）的生成强度和超氧化物歧化酶（SOD）活性。这些肿瘤细胞的特点是核膜生成O(-2)的强度与其SOD解毒作用之间失衡。这种失衡在生长迅速且对阿霉素高度敏感的胶质瘤35中尤为明显。生长缓慢的胶质瘤SOD活性较高，对阿霉素不敏感。由于已知蒽环类抗生素会提高肿瘤细胞中游离氧自由基的生成强度，所获得的数据表明，O(-2)的生成和解毒强度可用于评估对这些药物的敏感性。
