Izquierdo I, Dias R D
Braz J Med Biol Res. 1983 Apr;16(1):55-64.
The post-training amnestic effect of ACTH, beta-endorphin, adrenaline or tyramine on a step-down inhibitory avoidance task in rats was reversed by the administration of the same drugs prior to testing. Each drug was more effective as an anti-amnestic agent when the amnesia was induced by post-training administration of the same drug than of one of the others. alpha 2-Adrenergic receptors were shown to be involved in the amnestic and anti-amnestic actions of all the drugs and alpha 1 receptors to be involved in the anti-amnestic action of adrenaline and tyramine. These findings support the concept that memory depends on the relationship between the neurohumoral and hormonal states both after training and at the time of testing. These drugs would have limited value as contextual cues, and the mechanisms sensitive to their influence should be those involved in the availability of stored information for retrieval.
促肾上腺皮质激素、β-内啡肽、肾上腺素或酪胺在训练后对大鼠一步被动回避任务的遗忘效应，在测试前给予相同药物后被逆转。当遗忘是由训练后给予相同药物而非其他药物之一诱导时，每种药物作为抗遗忘剂更有效。已表明α2-肾上腺素能受体参与所有药物的遗忘和抗遗忘作用，α1受体参与肾上腺素和酪胺的抗遗忘作用。这些发现支持这样的概念，即记忆取决于训练后和测试时神经体液状态与激素状态之间的关系。这些药物作为情境线索的价值有限，对其影响敏感的机制应该是那些参与存储信息可检索性的机制。
