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有证据表明，源自中缝背核的γ-氨基丁酸能（GABAergic）对5-羟色胺能神经元具有抑制性影响。

Evidence for a GABAergic inhibitory influence on serotonergic neurons originating from the dorsal raphe.

作者信息

Nishikawa T, Scatton B

出版信息

Brain Res. 1983 Nov 21;279(1-2):325-9. doi: 10.1016/0006-8993(83)90203-2.

DOI:10.1016/0006-8993(83)90203-2
PMID:6315176
Abstract

Systemic administration of progabide, dipropylacetamide and gamma-acetylenic-GABA diminished striatal 5-HTP accumulation; the effect of progabide was abolished after hemitransection. Intradorsal raphé (but not intrastriatal) infusion of GABA or GABA agonist agents reduced striatal 5-HTP accumulation. Infusion of picrotoxinin or bicuculline into the dorsal raphé was without effect. It is concluded that GABA exerts an inhibitory influence on striatal serotonergic transmission via stimulation of GABA receptors located in the dorsal raphé.

摘要

全身给予普罗加比、二丙基乙酰胺和γ-乙炔基-GABA可减少纹状体5-羟色氨酸（5-HTP）的积累；在半横断后，普罗加比的作用消失。向背侧中缝核（而非纹状体内）注入GABA或GABA激动剂可减少纹状体5-HTP的积累。向背侧中缝核注入印防己毒素或荷包牡丹碱则无作用。得出的结论是，GABA通过刺激位于背侧中缝核的GABA受体，对纹状体5-羟色胺能传递发挥抑制作用。

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Evidence for a GABAergic inhibitory influence on serotonergic neurons originating from the dorsal raphe.有证据表明，源自中缝背核的γ-氨基丁酸能（GABAergic）对5-羟色胺能神经元具有抑制性影响。
Brain Res. 1983 Nov 21;279(1-2):325-9. doi: 10.1016/0006-8993(83)90203-2.
2
Inhibitory GABAergic influence on striatal serotonergic transmission exerted in the dorsal raphe as revealed by in vivo voltammetry.体内伏安法揭示了背侧中缝核中抑制性γ-氨基丁酸能对纹状体5-羟色胺能传递的影响。
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J Pharmacol Exp Ther. 1983 Nov;227(2):517-23.

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