Deisz R A, Dose M
Brain Res Bull. 1983 Sep;11(3):283-8. doi: 10.1016/0361-9230(83)90161-2.
The conductance increase induced by GABA and structurally related compounds has been measured in voltage clamped stretch receptor neurones of crayfish. GABA induced only at 10(-3) M a rapid conductance increase. The response to lower concentrations between 10(-6) and 10(-4) M developed slowly (20-60 min). The postsynaptic conductance increase induced by repetitive application of the same GABA concentration was progressively enhanced in the speed and magnitude. In the presence of nipecotic acid or in Na+-free Ringer solutions, the response to all GABA concentrations was instantaneous and constant for each concentration. Muscimol between 10(-6) and 10(-3) M caused instantaneous dose-dependent conductance increases. These results suggest the presence of a saturable GABA uptake system limiting the access of bath applied GABA, but not of muscimol, to postsynaptic receptor sites.
在对小龙虾电压钳制的牵张感受器神经元中，已测量了由γ-氨基丁酸（GABA）和结构相关化合物诱导的电导增加。GABA仅在10⁻³M浓度时诱导快速的电导增加。对10⁻⁶至10⁻⁴M之间较低浓度的反应发展缓慢（20 - 60分钟）。重复施加相同GABA浓度所诱导的突触后电导增加在速度和幅度上逐渐增强。在存在尼克酸或无钠林格溶液的情况下，对所有GABA浓度的反应对于每种浓度都是瞬时且恒定的。10⁻⁶至10⁻³M之间的蝇蕈醇引起瞬时剂量依赖性的电导增加。这些结果表明存在一个可饱和的GABA摄取系统，它限制了浴槽中施加的GABA（而非蝇蕈醇）到达突触后受体位点。
