Barney C C, Rutt D A, Katovich M J
Can J Physiol Pharmacol. 1983 Oct;61(10):1101-8. doi: 10.1139/y83-165.
Male rats were deprived of food for varying lengths of time (0-96 h) and their responses to beta-adrenergic stimulation with isoproterenol were tested. Food deprivation for 48 or 96 h attenuated the increase in tail skin temperature normally seen following administration of isoproterenol. The degree of attenuation was dependent on the duration of the deprivation period. Rats deprived of food for 96 h and then refed for 48, 96, or 144 h showed a return of tail skin temperature response to near normal levels. The increase in heart rate observed following administration of isoproterenol was also attenuated following 48 or 96 h of food deprivation. Again, the degree of attenuation was dependent on the duration of the deprivation period. Food deprivation for 96 h led to a decrease in basal plasma levels of T3, T4, and glucose. The increase in plasma glucose following administration of isoproterenol was also attenuated following 96 h of food deprivation. In contrast to the thermal, cardiac, and glucose responses, the dipsogenic response to isoproterenol was increased following food deprivation. The attenuation in beta-adrenergic responses observed in the food-deprived rats might help explain the effects of food deprivation on cold tolerance.
将雄性大鼠禁食不同时长（0 - 96小时），并测试它们对异丙肾上腺素β - 肾上腺素能刺激的反应。禁食48或96小时会减弱通常在给予异丙肾上腺素后出现的尾部皮肤温度升高。减弱程度取决于禁食期的时长。禁食96小时的大鼠，然后再喂食48、96或144小时，尾部皮肤温度反应恢复到接近正常水平。给予异丙肾上腺素后观察到的心率增加在禁食48或96小时后也会减弱。同样，减弱程度取决于禁食期的时长。禁食96小时导致基础血浆中T3、T4和葡萄糖水平下降。禁食96小时后，给予异丙肾上腺素后血浆葡萄糖的增加也会减弱。与热、心脏和葡萄糖反应相反，禁食后对异丙肾上腺素的致渴反应增强。在禁食大鼠中观察到的β - 肾上腺素能反应减弱可能有助于解释禁食对耐寒性的影响。
