1α,25-二羟基维生素D3显著增强化学诱导的BALB 3T3细胞转化。
1 alpha,25-Dihydroxyvitamin D3 markedly enhances chemically-induced transformation in BALB 3T3 cells.
作者信息
Kuroki T, Sasaki K, Chida K, Abe E, Suda T
出版信息
Gan. 1983 Oct;74(5):611-4.
PMID:6315520
Abstract
1 alpha,25-Dihydroxyvitamin D3, a hormonally active form of vitamin D3, enhanced methylcholanthrene-induced transformation in BALB 3T3 cells to a much greater extent than 12-O-tetradecanoylphorbol-13-acetate. This enhancement was probably mediated by a cytosol receptor for 1 alpha,25-dihydroxyvitamin D3 which has an equilibrium constant of 28.4pM and a maximum binding of 32.6 fmol/mg protein.
摘要
1α,25-二羟维生素D3，一种维生素D3的激素活性形式，比12-O-十四烷酰佛波醇-13-乙酸酯在更大程度上增强了苯并[a]芘诱导的BALB 3T3细胞转化。这种增强可能是由1α,25-二羟维生素D3的胞质溶胶受体介导的，该受体的平衡常数为28.4pM，最大结合量为32.6 fmol/mg蛋白质。
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