Mishiro S, Hayashi S, Tanaka N, Sato Y, Yamada S, Ogata I, Takatsuki K, Ota Y, Fujiwara K, Oka H
J Med. 1983;14(3):185-92.
A retrospective investigation of 21 cases of hepatocellular carcinoma with liver cirrhosis presumably of viral origin revealed a significant fall in the value of the zinc turbidity test from 15.5 +/- 6.9 (mean +/- SD) at 1 year to 11.2 +/- 2.5 units at 6 months before the discovery of the carcinoma (p less than 0.05), and a return to 16.8 +/- 7.2 units one month after the diagnosis (p less than 0.05). The values at 6, 2 and 1 month before the diagnosis were significantly lower than that for 120 control cirrhotics without hepatocellular carcinoma at 16.3 +/- 7.2 units (p less than 0.05). The fall in value occurred before or concurrently with a rise in the alpha-fetoprotein level in three patients, in whom it has been determined serially. Based on the results obtained, the decrease in the zinc turbidity test value may be used as an indicator for impending hepatocellular carcinoma in patients with liver cirrhosis.
对21例推测由病毒引起的肝硬化合并肝细胞癌患者进行的回顾性调查显示，锌浊度试验值从发现癌症前1年的15.5±6.9（均值±标准差）显著降至发现癌症前6个月的11.2±2.5单位（p<0.05），诊断后1个月又回升至16.8±7.2单位（p<0.05）。诊断前6个月、2个月和1个月时的值显著低于120例无肝细胞癌的对照肝硬化患者的16.3±7.2单位（p<0.05）。在3例连续检测甲胎蛋白水平的患者中，锌浊度试验值下降发生在甲胎蛋白水平升高之前或同时。根据所得结果，锌浊度试验值的降低可用作肝硬化患者即将发生肝细胞癌的指标。
