Speelman D J, Lund H, Culling A, Kittredge J S, Williams B J, Albrecht T
J Gen Virol. 1983 Nov;64 (Pt 11):2511-5. doi: 10.1099/0022-1317-64-11-2511.
The rates of virus inactivation by 4-nitroquinoline 1-oxide (NQO) and 4-hydroxyaminoquinoline 1-oxide (HAQO) were compared and samples of cytomegalovirus (CMV)-infected cell lysates to which NQO had been added were examined for the presence of HAQO. These experiments demonstrated that (i) CMV inactivation by HAQO was more rapid than with NQO, (ii) virus inactivation by either NQO or HAQO failed to demonstrate a photodynamic component, and (iii) NQO-treated stocks contained HAQO, indicating reduction of NQO to HAQO. The results support the concept that metabolism of NQO to HAQO enhances the genotoxic effect of NQO.
比较了4-硝基喹啉-1-氧化物（NQO）和4-羟基氨基喹啉-1-氧化物（HAQO）对病毒的灭活率，并检测了添加NQO的巨细胞病毒（CMV）感染细胞裂解物样本中HAQO的存在情况。这些实验表明：（i）HAQO对CMV的灭活比NQO更快；（ii）NQO或HAQO对病毒的灭活均未显示出光动力成分；（iii）经NQO处理的储备液中含有HAQO，表明NQO被还原为HAQO。这些结果支持了NQO代谢为HAQO会增强NQO遗传毒性作用的观点。
