Suzuki Y, Lederis K, Huang M, LeBlanc F E, Rorstad O P
Life Sci. 1983 Dec 19;33(25):2497-503. doi: 10.1016/0024-3205(83)90158-3.
We have studied the relaxant effect of bovine parathyroid hormone (bPTH) on helical strips of branches of bovine and human middle cerebral arteries and bovine and porcine basilar arteries. All arteries were studied after contraction with prostaglandin (PG) F2 alpha or KCl. In the case of all arteries contracted with PGF2 alpha, the ED50 of PTH vasorelaxation related to maximal vasorelaxation induced by papaverine ranged from 9 to 14 nM for bPTH-(1-34) and 100 to 220 ng/ml for native bPTH-(1-84). The PTH inhibitor, [Nle8, Nle18, Tyr34]bPTH-(3-34) amide, attenuated the vasorelaxant effect of both bPTH-(1-34) and bPTH-(1-84). The vasorelaxant effects of PTH which we have observed in this study are consistent with the stimulatory effects of PTH on vascular adenylate cyclase which we had previously reported.
我们研究了牛甲状旁腺激素（bPTH）对牛和人大脑中动脉分支以及牛和猪基底动脉螺旋条的舒张作用。所有动脉均在经前列腺素（PG）F2α或氯化钾收缩后进行研究。在所有经PGF2α收缩的动脉中，与罂粟碱诱导的最大血管舒张相关的PTH血管舒张的半数有效剂量（ED50），对于bPTH -（1 - 34）为9至14 nM，对于天然bPTH -（1 - 84）为100至220 ng/ml。PTH抑制剂[Nle8，Nle18，Tyr34]bPTH -（3 - 34）酰胺减弱了bPTH -（1 - 34）和bPTH -（1 - 84）的血管舒张作用。我们在本研究中观察到的PTH的血管舒张作用与我们之前报道的PTH对血管腺苷酸环化酶的刺激作用一致。
