Rathbun R C, Kattau R W, Leander J D
Pharmacol Biochem Behav. 1983 Nov;19(5):863-6. doi: 10.1016/0091-3057(83)90094-1.
The effects of ethylketazocine, morphine, bremazocine and naloxone were determined on urinary output and weight loss in Cox mice. Morphine and fentanyl were also studied in Harlan mice. Bremazocine, ethylketazocine and morphine markedly increased urinary output and weight loss within 5 hr after injection. Naloxone antagonized the diuretic actions of morphine (5 mg/kg) and bremazocine (0.06 mg/kg) over a similar dose range (0.3--10 mg/kg). By comparison with the other agonists, fentanyl had little effect on urinary output or weight loss. These results suggest that kappa agonist activity increases urinary output in mice just as reported for rats. The data also suggest that in mice morphine has some kappa agonist activity, whereas fentanyl does not.
研究了乙基酮佐辛、吗啡、布瑞马佐辛和纳洛酮对考克斯小鼠尿量和体重减轻的影响。还在哈兰小鼠中研究了吗啡和芬太尼。布瑞马佐辛、乙基酮佐辛和吗啡在注射后5小时内显著增加尿量和体重减轻。纳洛酮在相似剂量范围（0.3 - 10mg/kg）内拮抗吗啡（5mg/kg）和布瑞马佐辛（0.06mg/kg）的利尿作用。与其他激动剂相比，芬太尼对尿量或体重减轻几乎没有影响。这些结果表明，κ激动剂活性可增加小鼠尿量，正如在大鼠中所报道的那样。数据还表明，在小鼠中吗啡具有一定的κ激动剂活性，而芬太尼则没有。
