持续空肠灌注要素膳和复合营养溶液对人体胰腺酶分泌的影响。
Effect of continuous jejunal perfusion of elemental and complex nutritional solutions on pancreatic enzyme secretion in human subjects.
作者信息
Vison N, Hecketsweiler P, Butel J, Bernier J J
出版信息
Gut. 1978 Mar;19(3):194-8. doi: 10.1136/gut.19.3.194.
Abstract
Pancreatic secretion of lipase and chymotrypsin in response to elemental diets and a crushed food homogenate was studied in normal subjects. The solutions were infused at constant flow rates at the ligament of Treitz with polyethylene glycol as a nonabsorbable marker. A triple lumen tube was used, enabling collection of secretions at 35 and 70 cm from the infusion point. The results show that a crushed food homogenate has a greater stimulative effect on pancreatic enzyme secretion than the elemental solutions and that this can be directly related to its greater nitrogen content. The osmolality of the infused solutions does not appear to be important. The relative merits of the solutions tested and total parental nutrition in reducing pancreatic enzyme secretion are discussed.
摘要
在正常受试者中研究了胰腺对要素饮食和粉碎食物匀浆的脂肪酶和胰凝乳蛋白酶分泌反应。溶液以恒定流速在屈氏韧带处输注，使用聚乙二醇作为不可吸收标记物。使用三腔管，能够在距输注点35和70厘米处收集分泌物。结果表明，粉碎食物匀浆对胰腺酶分泌的刺激作用比要素溶液更大，这可能与其更高的氮含量直接相关。输注溶液的渗透压似乎并不重要。讨论了所测试溶液和全胃肠外营养在减少胰腺酶分泌方面的相对优点。
相似文献
1
Effect of continuous jejunal perfusion of elemental and complex nutritional solutions on pancreatic enzyme secretion in human subjects.持续空肠灌注要素膳和复合营养溶液对人体胰腺酶分泌的影响。
Gut. 1978 Mar;19(3):194-8. doi: 10.1136/gut.19.3.194.
2
Absorption of elemental and complex nutritional solutions during a continuous jejunal perfusion in man.人体空肠持续灌注期间对元素性和复合营养溶液的吸收。
Digestion. 1979;19(3):213-7. doi: 10.1159/000198347.
3
Effect of jejunal infusion of different caloric loads on pancreatic enzyme secretion and gastro-intestinal hormone response in man.
Eur J Clin Invest. 1993 Jan;23(1):57-62. doi: 10.1111/j.1365-2362.1993.tb00718.x.
4
[Effect of the nitrogen components of a peptide diet and the analogous amino acids on pancreatic secretion in the human].
Z Gastroenterol. 1982 Nov;20(11):681-7.
5
Effect of different caloric loads in human jejunum on meal-stimulated and nonstimulated biliopancreatic secretion.
Am J Clin Nutr. 1988 Mar;47(3):400-5. doi: 10.1093/ajcn/47.3.400.
6
Does jejunal feeding with a polymeric immune-enhancing formula increase pancreatic exocrine output as compared with TPN? A case report.
Nutrition. 2000 Jan;16(1):47-9. doi: 10.1016/s0899-9007(99)00225-7.
7
Cholecystokinin release and biliopancreatic secretion in response to selective perfusion of the duodenal loop with aminoacids in man.人体十二指肠袢选择性灌注氨基酸后胆囊收缩素释放及胆胰分泌情况
Gut. 1988 Sep;29(9):1158-66. doi: 10.1136/gut.29.9.1158.
8
Effect of intrajejunal elemental diet perfusion on jejunal secretion of immunoglobulins, albumin, and hyaluronan in man.空肠内要素饮食灌注对人体空肠免疫球蛋白、白蛋白和透明质酸分泌的影响。
Gut. 1992 Jan;33(1):44-7. doi: 10.1136/gut.33.1.44.
9
Feedback regulation by trypsin: evidence for intraluminal CCK-releasing peptide.胰蛋白酶的反馈调节：腔内胆囊收缩素释放肽的证据。
Am J Physiol. 1989 Aug;257(2 Pt 1):G175-81. doi: 10.1152/ajpgi.1989.257.2.G175.
10
Adaptive changes of pancreatic protease secretion to a short-term vegan diet: influence of reduced intake and modification of protein.胰腺蛋白酶分泌对短期纯素饮食的适应性变化：减少摄入量和蛋白质修饰的影响。
Br J Nutr. 2012 Jan;107(2):272-6. doi: 10.1017/S0007114511002923. Epub 2011 Jul 13.
引用本文的文献
1
Association between fibrinogen levels and prognosis in critically bleeding patients: exploration of the optimal therapeutic threshold.严重出血患者纤维蛋白原水平与预后的关系：最佳治疗阈值的探索
Eur J Trauma Emerg Surg. 2025 May 23;51(1):219. doi: 10.1007/s00068-025-02886-8.
2
Nutrition in Acute Pancreatitis: From the Old Paradigm to the New Evidence.急性胰腺炎的营养治疗：从旧观念到新证据。
Nutrients. 2023 Apr 18;15(8):1939. doi: 10.3390/nu15081939.
3
Comparative effectiveness of elemental formula in the early enteral nutrition management of acute pancreatitis: a retrospective cohort study.要素型肠内营养制剂在急性胰腺炎早期肠内营养管理中的比较效果：一项回顾性队列研究
Ann Intensive Care. 2018 Jun 5;8(1):69. doi: 10.1186/s13613-018-0414-6.
4
Post-pyloric feeding.幽门后喂养
World J Gastroenterol. 2009 Mar 21;15(11):1281-8. doi: 10.3748/wjg.15.1281.
5
The role of the intestine in the pathophysiology and management of severe acute pancreatitis.肠道在重症急性胰腺炎病理生理学及治疗中的作用
HPB (Oxford). 2003;5(2):69-85. doi: 10.1080/13651820310001108.
6
Parenteral versus early intrajejunal nutrition: effect on pancreatitic natural course, entero-hormones release and its efficacy on dogs with acute pancreatitis.肠外营养与早期空肠内营养：对急性胰腺炎犬胰腺炎自然病程、肠激素释放及其疗效的影响
World J Gastroenterol. 2003 Oct;9(10):2270-3. doi: 10.3748/wjg.v9.i10.2270.
7
Enteral nutrition and acute pancreatitis.肠内营养与急性胰腺炎
World J Gastroenterol. 2001 Apr;7(2):185-92. doi: 10.3748/wjg.v7.i2.185.
8
Assessment of pancreatic enzyme secretory capacity by a modified Lundh test.通过改良的伦德试验评估胰腺酶分泌能力。
Int J Pancreatol. 2000 Feb;27(1):13-9. doi: 10.1385/IJGC:27:1:13.
9
Clinical nutrition in pancreatitis.胰腺炎的临床营养
Dig Dis Sci. 1997 Oct;42(10):2035-44. doi: 10.1023/a:1018806131924.
10
Bile acid and pancreatic trypsin outputs are parallel during intraduodenal infusion of essential amino acids.在十二指肠内输注必需氨基酸期间，胆汁酸和胰蛋白酶的分泌量是平行的。
Dig Dis Sci. 1983 Jan;28(1):27-32. doi: 10.1007/BF01393357.
本文引用的文献
1
Physiological determination of release of secretin and pancreozymin from intestine of dogs with transplanted pancreas.移植胰腺犬肠道中促胰液素和缩胆囊素释放的生理学测定
Am J Physiol. 1951 Feb;164(2):527-45. doi: 10.1152/ajplegacy.1951.164.2.527.
2
Distribution and fate of pancreatic enzymes in small intestine of the rat.大鼠小肠中胰腺酶的分布与去向
Am J Physiol. 1962 Feb;202:285-8. doi: 10.1152/ajplegacy.1962.202.2.285.
3
[DETERMINATION OF CHYMOTRYPSIN AND TRYPSIN IN DUODENAL JUICE].[十二指肠液中胰凝乳蛋白酶和胰蛋白酶的测定]
Bull Soc Chim Biol (Paris). 1965;47:679-86.
4
Influences of hexamethonium and some dietary factors on human pancreatic and bile secretion.六甲铵及某些饮食因素对人体胰腺和胆汁分泌的影响。
J Appl Physiol. 1961 Sep;16:810-4. doi: 10.1152/jappl.1961.16.5.810.
5
Purification of hog pancreatic lipase.猪胰脂肪酶的纯化
Arch Biochem Biophys. 1959 Jul;83(1):309-19. doi: 10.1016/0003-9861(59)90036-0.
6
Studies of intestinal digestion and absorption in the human.人体肠道消化与吸收的研究。
J Clin Invest. 1957 Oct;36(10):1521-36. doi: 10.1172/JCI103549.
7
The prophylactic use of an "elemental" diet in experimental hemorrhagic shock and intestinal ischemia.“要素”饮食在实验性失血性休克和肠道缺血中的预防性应用。
Ann Surg. 1967 Sep;166(3):312-43. doi: 10.1097/00000658-196709000-00002.
8
Use of polyethylene glycol in investigations of absorption of fat.聚乙二醇在脂肪吸收研究中的应用。
Nature. 1965 Oct 16;208(5007):293-4. doi: 10.1038/208293a0.
9
10
Pancreozymin bioassay in man based on pancreatic enzyme secretion: potency of specific amino acids and other digestive products.基于胰腺酶分泌的人胰酶泌素生物测定法：特定氨基酸和其他消化产物的效力
J Clin Invest. 1970 Aug;49(8):1558-64. doi: 10.1172/JCI106373.
Zotero 插件