Schmitt G, Schnabel K, Scherer E, Schulz U
Radiologe. 1983 Nov;23(11):518-22.
Postoperative photon- or electron irradiation has been well established in the treatment of soft tissue sarcomas. For further improvement of these results, neutron- or neutron-boost irradiation was introduced at several centres of radiation therapy. In this report, the 3.5 year results of 112 patients are analysed. The majority (62%) had T3-tumours (UICC classification, Geneva 1978). 58 patients presented with gross tumour at the beginning of radiotherapy, and 54 patients without clinical evidence of tumour. 39 patients (35%) had recurrent tumours. A highly statistical difference in local tumour control was found between the group of patients with gross tumour (47%) and the group of patients without clinical evidence of tumour (81%). A statistical difference in local control and survival was also found between the group of patients with T1-tumours (100%), T2 tumours (76.8%) and T3 tumours (44.5%), whereas no differences were found in terms of grading. The high complication rate of 25%, which was found after neutron therapy, was reduced to 7% after introduction of a neutron boost. The statistical significance of this treatment modality is presently being evaluated in a randomised EORTC trial. Adjuvant chemotherapy is recommended für all G3 tumours.
术后光子或电子照射在软组织肉瘤的治疗中已得到充分确立。为进一步改善这些结果，几个放射治疗中心引入了中子或中子增强照射。在本报告中，分析了112例患者的3.5年结果。大多数（62%）患有T3期肿瘤（UICC分类，1978年日内瓦）。58例患者在放疗开始时出现肉眼可见肿瘤，54例患者无肿瘤临床证据。39例患者（35%）有复发性肿瘤。在有肉眼可见肿瘤的患者组（47%）和无肿瘤临床证据的患者组（81%）之间，发现局部肿瘤控制存在高度统计学差异。在T1期肿瘤患者组（100%）、T2期肿瘤患者组（76.8%）和T3期肿瘤患者组（44.5%）之间，也发现了局部控制和生存率的统计学差异，而在分级方面未发现差异。中子治疗后发现的25%的高并发症率在引入中子增强后降至7%。这种治疗方式的统计学意义目前正在一项随机的欧洲癌症研究与治疗组织（EORTC）试验中进行评估。建议对所有G3期肿瘤进行辅助化疗。
